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Hyper-stimulation of low-grade inflammatory mediators triggers peripheral endotoxemia and a persistent inflammatory state, popularly called inflammaging (reviewed in Mechanistic Insight Into Gut Microbiome-Mediated Neurodegeneration A clear pathophysiological link between immune and metabolic dysregulation and neurodegenerative disorders in the brain had been previously established (reviewed in Yan et al., 2020)

Additionally, HCC CSCs hijack TAM SIPR-CD47's Dont eat me signaling pathway to evade immune surveillance and prevent them from being phagocytosed by macrophages [160]